The CIR Expert Panel evaluated scientific data and concluded that Retinol and Retinyl Palmitate were safe as cosmetic ingredients. In 2005, the CIR Expert Panel considered available new data on Retinol and Retinyl Palmitate and reaffirmed their conclusion.  CIR Review: The CIR Expert Panel noted that vitamin A is an essential nutrient with a Recommended Daily Allowance orally that varies for different groups: 5000 and 4000 International Units (IU) daily for male and female adults, respectively; lesser amounts for infants and children; and 5000 and 6000 IU daily for pregnant and lactating women, respectively.

The CIR Expert Panel reviewed the safety data on Retinol and Retinyl Palmitate and concluded that these ingredients were not mutagenic or carcinogenic. Cosmetics and personal care products containing 0.1-1% of these ingredients were at most slightly irritating. These products did not result in skin sensitization.  In addition Retinyl Palmitate and Retinol may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.  Health Canada permits the use of Retinyl Palmitate and Retinol in cosmetics and personal care products at concentrations equal to or less than 1%.
The state of California lists Retinol and retinyl esters, including Retinyl Palmitate, as Proposition 65 chemicals “known to the state” to cause reproductive toxicity at daily dosages in excess of 10,000 IU.   Cosmetics and personal care products do not contain large amounts of Retinol and retinyl esters, including Retinyl Palmitate, and these ingredients dermally applied do substantially contribute to the amount of vitamin A in the blood (more than 10,000 IU). Therefore, cosmetics and personal care products containing Retinol and Retinyl Palmitate do not need to be labeled with a Proposition 65 warning.
 
Sun Alert: This product contains a retinyl palmitate that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product.